Isabelle Aerts Selected Research

Investigational Therapies (Experimental Therapy)

1/2021	Phase II and biomarker study of programmed cell death protein 1 inhibitor nivolumab and metronomic cyclophosphamide in paediatric relapsed/refractory solid tumours: Arm G of AcSé-ESMART, a trial of the European Innovative Therapies for Children With Cancer Consortium.
12/2020	Impact of COVID-19 in paediatric early-phase cancer clinical trials in Europe: A report from the Innovative Therapies for Children with Cancer (ITCC) consortium.
3/2018	Outcome of children and adolescents with central nervous system tumors in phase I trials.
1/2018	Phase I results of a phase I/II study of weekly nab-paclitaxel in paediatric patients with recurrent/refractory solid tumours: A collaboration with innovative therapies for children with cancer.
11/2016	Prognostic factors of overall survival in children and adolescents enrolled in dose-finding trials in Europe: An Innovative Therapies for Children with Cancer study.
1/2014	Phase II study of temozolomide in combination with topotecan (TOTEM) in relapsed or refractory neuroblastoma: a European Innovative Therapies for Children with Cancer-SIOP-European Neuroblastoma study.
2/2012	A phase I and pharmacokinetic study of plitidepsin in children with advanced solid tumours: an Innovative Therapies for Children with Cancer (ITCC) study.
1/2011	Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors.
1/2011	Phase II study of gemcitabine combined with oxaliplatin in relapsed or refractory paediatric solid malignancies: An innovative therapy for children with Cancer European Consortium Study.

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Isabelle Aerts Research Topics

Disease

44	Neoplasms (Cancer) 01/2022 - 12/2003
23	Retinoblastoma (Glioblastoma, Retinal) 01/2022 - 07/2004
5	Brain Neoplasms (Brain Tumor) 01/2022 - 01/2011
5	Glioma (Gliomas) 01/2022 - 01/2011
5	Neoplasm Metastasis (Metastasis) 10/2021 - 12/2011
4	Medulloblastoma 01/2020 - 09/2013
2	Genetic Predisposition to Disease (Genetic Predisposition) 12/2021 - 01/2020
2	Disease Progression 01/2021 - 01/2020
2	Margins of Excision 01/2021 - 04/2013
2	Hepatoblastoma 01/2019 - 02/2017
2	Thrombocytopenia (Thrombopenia) 12/2016 - 10/2010
2	Ewing Sarcoma (Sarcoma, Ewing) 01/2016 - 12/2011
2	Neuroblastoma 01/2014 - 01/2006
1	Hypothyroidism 01/2022
1	Thyroid Nodule (Nodule, Thyroid) 01/2022
1	Toxic Optic Neuropathy 01/2022
1	Liver Neoplasms (Liver Cancer) 10/2021
1	Cicatrix (Scar) 01/2021
1	Osteosarcoma (Osteogenic Sarcoma) 01/2021
1	Lymphopenia (Lymphocytopenia) 01/2021
1	Hypotension (Low Blood Pressure) 01/2021
1	Ischemia 01/2021
1	COVID-19 12/2020
1	Hypoxia (Hypoxemia) 10/2020
1	Central Nervous System Neoplasms 01/2020
1	Primitive Neuroectodermal Tumors (PNET) 01/2020
1	Arthralgia (Joint Pain) 12/2019
1	Exanthema (Rash) 12/2019
1	Necrosis 01/2019
1	Pneumothorax 01/2019
1	Ependymoma 01/2018
1	Breast Neoplasms (Breast Cancer) 01/2018

Drug/Important Bio-Agent (IBA)

6	Temozolomide (Temodar)FDA LinkGeneric 11/2021 - 10/2010
5	Topotecan (Hycamtin)FDA LinkGeneric 11/2021 - 10/2010
3	Cell-Free Nucleic AcidsIBA 01/2022 - 01/2021
3	Biomarkers (Surrogate Marker)IBA 12/2021 - 05/2017
3	Etoposide (VP 16)FDA LinkGeneric 01/2021 - 12/2003
3	Retinaldehyde (Retinal)IBA 01/2021 - 01/2017
3	Irinotecan (Camptosar)FDA LinkGeneric 10/2020 - 07/2012
3	Pharmaceutical PreparationsIBA 12/2019 - 01/2018
3	Carboplatin (JM8)FDA LinkGeneric 09/2016 - 08/2008
2	SuspensionsIBA 01/2022 - 01/2017
2	Sirolimus (Rapamycin)FDA Link 11/2021 - 10/2020
2	Cisplatin (Platino)FDA LinkGeneric 10/2021 - 12/2003
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2021 - 12/2003
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 07/2012
2	Tyrosine Kinase InhibitorsIBA 01/2021 - 01/2020
2	Melphalan (Alkeran)FDA LinkGeneric 01/2021 - 07/2017
2	Ifosfamide FDA LinkGeneric 01/2021 - 12/2003
2	Bevacizumab (Avastin)FDA Link 09/2016 - 07/2012
2	1-phenyl-3,3-dimethyltriazene (PDT)IBA 12/2010 - 09/2009
1	Conditioned Culture MediaIBA 01/2022
1	Macrophage Migration-Inhibitory FactorsIBA 01/2022
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2022
1	Vinorelbine (Navelbine)FDA LinkGeneric 01/2022
1	CytokinesIBA 01/2022
1	Immune Checkpoint ProteinsIBA 01/2022
1	Basigin (Extracellular Matrix Metalloproteinase Inducer (EMMPRIN))IBA 01/2022
1	Proteins (Proteins, Gene)FDA Link 01/2022
1	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2022
1	cobimetinibIBA 01/2022
1	TabletsIBA 01/2022
1	DNA (Deoxyribonucleic Acid)IBA 12/2021
1	ribociclibIBA 11/2021
1	Everolimus FDA Link 11/2021
1	Mechanistic Target of Rapamycin Complex 1IBA 11/2021
1	vistusertibIBA 11/2021
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 11/2021
1	Circulating Tumor DNAIBA 01/2021
1	NivolumabIBA 01/2021
1	lenvatinibIBA 01/2021
1	Immune Checkpoint InhibitorsIBA 01/2021
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2021
1	Drug CombinationsIBA 01/2021
1	Biological ProductsIBA 01/2021
1	InterferonsIBA 01/2021
1	Retinoblastoma ProteinIBA 01/2020
1	Vinblastine (Vinblastine Sulfate)FDA Link 01/2020
1	nilotinib FDA Link 01/2020
1	dabrafenibIBA 12/2019
1	MB 5IBA 01/2018
1	130-nm albumin-bound paclitaxelIBA 01/2018

Therapy/Procedure

17	Therapeutics 12/2021 - 12/2003
14	Drug Therapy (Chemotherapy) 10/2021 - 12/2003
13	Radiotherapy 01/2022 - 12/2003
9	Investigational Therapies (Experimental Therapy) 01/2021 - 01/2011
4	Conservative Treatment 01/2021 - 08/2008
2	Salvage Therapy 01/2022 - 01/2011
2	Adjuvant Chemotherapy 01/2021 - 04/2013
2	Neoadjuvant Therapy 01/2020 - 08/2008
2	Induced Hyperthermia (Thermotherapy) 04/2015 - 08/2008
2	Aftercare (After-Treatment) 05/2013 - 05/2009
2	Photochemotherapy (Photodynamic Therapy) 12/2010 - 09/2009
1	Precision Medicine 01/2022
1	Pituitary Irradiation 01/2022
1	Immunomodulation 01/2020
1	Duration of Therapy 12/2019
1	Metastasectomy 01/2019
1	Radiofrequency Ablation 01/2019
1	Chest Tubes (Chest Tube) 01/2019